ハイブリドーマによるモノクローナル抗体の効率的生産に関する研究
食品の機能性（免疫増強、抗アレルギー、メタボリックシンドローム予防、抗ガン）に関する研究
培養装置による動物細胞の大量培養に関する研究
脂質膜ベシクルを用いたドラッグデリバリー系、および遺伝子ベクター系の開発
環境化学物質の生体リスク評価
硫酸転移酵素の遺伝子のクローニング、および諸性質の解明

1. Exploring the anti-inflammatory effect of clove water extract in lipopolysaccharide-stimulated RAW264.7 cells and mouse peritoneal macrophages., Journal of Food Bioactives, In press, 2024.
2. Cross-species amplifications from non-human primate DNAs on commercial human DNA assay kits., Legal Medicine, 68, #102369, 2024.
   [DOI]
3. Immunostimulation mechanisms of jellyfish collagen on mouse bone marrow-derived dendritic cells., Proceedings of the 9th International Symposium on Innovative Bioproduction Indonesia on Biotechnology and Bioengineering 2022, 080007, 1-7, 2023.
   [DOI]
4. Anti-inflammatory potentials of Rendang seasoning (Sumatran traditional food) water extract in RAW264.7 cells and mouse peritoneal macrophages., Journal of Functional Food and Nutraceutical, 5(1), 2023.
   [DOI]
5. Isolation and quantification of 2-o-caffeoyl-hydroxycitric acid, an active component in hot water extracts of coriander (Coriandrum sativum L.), which inhibits degranulation of RBL-2H3 cells., Natural Product Communications, 18(7), 1-11, 2023.
   [DOI]
6. Effects of water hardness on the flavor and antioxidant activity of Ishizuchi dark tea., Food Chemistry Advances, 2, #100253, 2023.
   [ScienceDirect]
7. Syntheses of 6-(2-hydroxy-6-phenylhexyl)-5,6-dihydro-2H-pyran-2-one derivatives and their cytotoxicities., Phytochem. Lett., 52, 118-122, 2022.
8. Aqueous extract from Cuminum cyminum L. seed alleviates ovalbumin-induced allergic rhinitis in mouse via balancing of helper T cells., Foods, 11(10), #3224, 2022.
9. Identification of components in coriander (Coriandrum sativum L.) inhibiting degranulation of RBL-2H3 cells., Fitoterapia, 163, #105298, 2022.
10. Anti-allergic effect of aqueous extract of coriander (Coriandrum sativum L.) leaf in RBL-2H3 cells and cedar pollinosis model mice., Nutraceuticals, 2(3), 1701-180, 2022.
11. Umbelliferose isolated from Cuminum cyminum L. seeds inhibits antigen-induced degranulation in rat basophilic leukemia RBL-2H3 cells., Molecules, 27(13), #4101, 2022.
12. p-Synephrine suppresses inflammatory responses in lipopolysaccharide-stimulated RAW264.7 cells and alleviates systemic inflammatory response syndrome in mice., Food Funct., 13(9), 5229-5239, 2022.
13. Water and Ethanol Extracts of Tamarind (Tamarindus indica) Suppress Lipid Accumulation in 3T3-L1 Cells., Canrea Journal: Food Technology, Nutritions, and Culinary, 5(1), 1-11, 2022.
14. Advantages of filtration method for sperm-DNA genotyping in sexual assault cases., Legal Medicine, 54, 101988, 2022.
15. Aqueous extract from leaves of Citrus unshiu attenuates lipopolysaccharide-induced inflammatory responses in a mouse model of systemic inflammation., Plants, 10(8), 1708, 2021.
16. Screening of immunostimulatory activity from Indonesian native (Gallus domesticus) egg white water extract: in vitro study., Journal of Functional Food and Nutraceutical, 3(1), 1-10, 2021.
17. Stimulation of IgM production in HB4C5 cell line and mouse splenocytes by egg yolk extract from Indonesian native chicken egg. , Tropical Animal Science Journal, 44(4), 511-519, 2021.
18. ヨーグルト中のベータラクトグロブリンの簡易測定法としての酵素抗体法の有効性に関する考察, 日本食品科学工学会誌, 68(8), 356-359, 2021.
19. Hypocholesterolemic activity of kedawung (Parkia roxburghii) . , Indonesian Journal of Science & Technology, 6(2), 353-360, 2021.
20. Anti-allergy potential of Averrhoa bilimbi Linn. fruit water extract shown by its suppressive effect on the degranulation of RBL-2H3 cells., Journal of Functional Food and Nutraceutical, 2(2), 81-88, 2021.
21. Discovery of stereospecific cytotoxicity of (8R,8'R)-trans-arctigenin against insect cells and structure-activity relationship on aromatic ring., Bioorg. Med. Chem. Lett., 30(13), Article number 127191, 2020.
    [DOI]
22. Anti-melanogenic activity of methanolic extract from leaves of Sorbaria sorbifolia var. stellipila Max. on α-MSH-stimulated B16 melanoma 4A5 cells., Biomedical Dermatology, 4, 1-8, 2020.
    [DOI]
23. Trigonelline: an alkaloid with anti-degranulation properties., Mol. Immunol., 118, 201-109, 2020.
    [PubMed 31896496]
24. Anti-degranulation activity of caffeine: in vitro and in vivo study., J. Funct. Foods, 60, Article number 103422, 2019.
    [SAcienceDirect]
    [DOI]
25. Inhibitory effect of caffeine on degranulation of RBL-2H3 cells., Proceeding of the 5th International Conference on Agro-Industry (ICoA2018), 123-127, 2019.
26. Immature black vinegar extract activates macrophages., Proceeding of the 5th International Conference on Agro-Industry (ICoA2018), 92-97, 2019.
27. Anti-inflammatory effect of placenta water-soluble extract on macrophages., Proceeding of the 5th International Conference on Agro-Industry (ICoA2018), 98-103, 2019.
28. Anti-allergic effect of clove., Proceeding of the 5th International Conference on Agro-Industry (ICoA2018), 104-109, 2019.
29. Anti-inflammatory effect of aqueous extract from Kawachi-bankan peel on lipopolysaccharide-induced inflammatory responses in RAW264.7 cells., Proceeding of the 5th International Conference on Agro-Industry (ICoA2018), 110-114, 2019.
30. Anti-inflammatory effect of lysozyme., Proceeding of the 5th International Conference on Agro-Industry (ICoA2018), 115-122, 2019.
31. Cytotoxicity against HL60 cells of ficifolidione derivatives with methyl, n-pentyl, and n-heptyl groups., Molecules, 24(22), E4081, 2019.
    [PubMed 31718080]
32. Structure-activity relationships of fish oil derivatives with anti-allergic activity in vitro and in vivo., J. Med. Chem., 62(21), 9576-9592, 2019.
    [PubMed 31618024]
33. Docosahexaenoyl ethanolamide mitigates IgE-mediated allergic reactions by inhibiting mast cell degranulation and regulating allergy-related immune cells., Sci. Rep., 9(1), 16213, 2019.
    [PubMed 31700043]
34. A simple and versatile authenticity assay of coffee products by single nucleotide polymorphism genotyping., Biosci. Biotechnol. Biochem., 83(10), 1829-1836, 2019.
    [PubMed 31119972]
35. Anti-inflammatory effect of aqueous extract from Kawachi-bankan (Citrus maxima) peel in vitro and in vivo., Cytotechnology, 71(4), 797-807, 2019.
    [PubMed 31190318]
36. The design of 92 new 9-Norlignan derivatives and their effect on the cell viabilities of cancer and insect cells., J. Agric. Food Chem., 67(28), 7880-7885, 2019.
    [PubMed 31250636]
37. Inhibitory effect of aqueous extract of Cuminum cyminum L. seed on degranulation of RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice., Cytotechnology, 71(2), 599-609, 2019.
    [PubMed 30905011]
38. Lysozyme from hen egg white ameliorates lipopolysaccharide-induced systemic inflammation in mice., Cytotechnology, 71(2), 497-506, 2019.
    [PubMed 29497877]
39. Anti-inflammatory effect of arabica coffee extract (Coffea Arabica L.)., Proceedings of The 2nd Internatinal Conference on Life Sciences and Biotechnology (ICOLIB), 227-232, 2018.
40. Anti-allergy potential of petis extracy on immunoglobulin E production by U266 cells., Canrea Journal, 2(2), 136-142, 2018.
41. Inhibitory effect of Japanese black vinegar on IgE-mediated degranulation of RBL-2H3 cells and a murine model of Japanese cedar pollinosis., Cytotechnology, 70(3), 961-974, 2018.
    [PubMed 29500751]
42. Anti-inflammatory effect of lysozyme from hen egg white on mouse peritoneal macrophages., Cytotechnology, 70(3), 929-938, 2018.
    [PubMed 29497877]
43. Suppressive effect of ethanol extract from mango (Mangifera indica L.) peel on IgE production in vitro and in vivo., Biosci. Biotechnol. Biochem., 82(4),732-739, 2018.
    [PubMed 29297259]
44. IgE production-suppressing effect of asam kandis (dried Garcinia xantochymus) extracts by mouse hybridoma aDNP-Hy Cells., Biodiversitas, 19(1), 330-335, 2018.
45. Immunostimulatory effect of tempoyak (fermented durian) on inducing cytokine production (IL-6 and TNF-α) by RAW 264.7 cells., Biodiversitas, 19(1), 318-322, 2018.
46. Syntheses of cytotoxic novel arctigenin derivatives bearing halogen and alkyl groups on aromatic rings., Bioorg. Med. Chem. Lett., 27, 4199-4203, 2017.
    [PubMed 28754364]
47. Immunostimulatory effect of aqueous extract of Coriandrum sativum L. seed on macrophages., J. Sci. Food Agr., 97, 4727-4736, 2017.
    [PubMed 28369918]
48. Immunomodulatory activity of octenyl succinic anhydride modified porang (Amorphophallus oncophyllus) glucomannan on mouse macrophage-like J774.1 cells and mouse primary peritoneal macrophages., Molecules, 22(7), E1187, 2017.
    [PubMed 28714872]
49. Effect of mandarin orange yogurt on allergic conjunctivitis induced by conjunctival allergen challenge., Invest. Ophth. Vis. Sci., 58, 2922-2929, 2017.
    [PubMed 28593244]
50. Immunostimulatory effect of dried bonito extract on mouse Macrophage cell lines and mouse primary peritoneal macrophages., Cytotechnology, 69, 229-244, 2017.
    [PubMed 28084562]
51. Suppressive effect of ethanol extract from passion fruit seeds on IgE production., J. Funct. Foods, 32, 176-184, 2017.
52. Immunostimulatory activity of snake fruit peel extract on murine macrophage-like J774.1 cells., Cytotechnology, 68, 1737-1745, 2016.
    [PubMed 26482737]
53. Efficacy of chlorophyll c2 for seasonal allergic rhinitis; single-center double blind randomized control trial., Eur. Arch. Oto Rhino Laryngol., 273, 4289-4294, 2016.
    [PubMed 27277115]
54. Nobiletin suppresses monocyte chemoattractant protein-1 (MCP-1) expression by regulating MAPK signalling in 3T3-L1 cells., J. Funct. Foods, 27, 406-415, 2016.
    [ScinceDirect]
55. Inhibitory effects of enzyme-treated dried sardine extract on IgE-mediated degranulation of RBL-2H3 cells and a murine model of Japanese cedar pollinosis., RSC Advances, 6, 85718-85726, 2016.
56. Immunostimulatory effect of spinach aqueous extract on mouse macrophage-like J774.1 cells and mouse primary peritoneal macrophages., Biosci. Biotechnol. Biochem., 80, 1393-1402, 2016.
    [PubMed 27095137]
57. Effects of an equol-producing bacterium isolated from human feces on isoflavone and lignan metabolism in mice., J. Sci. Food Agr., 96, 3126-3132, 2016.
    [PubMed 26455424]
58. Enantioselective syntheses of both enantiomers of 9'-dehydroxyimperanene and 7,8-dihydro-9'-dehydroxyimperanene and the comparison of biological activity between 9-norlignans and dihydroguaiaretic acids., Bioorg. Med. Chem. Lett., 26, 3019-3023, 2016.
    [PubMed 27210431]
59. Effect of concurrent administration of nobiletin and β-lactoglobulin on the symptoms of Japanese cedar pollinosis models in mice., J. Funct. Foods, 22, 389-397, 2016.
    [ScinceDirect]
60. Effect of the structure of dietary epoxylignan on its cytotoxic activity: relationship between the structure and the activity of 7,7'-epoxylignan and the introduction of apoptosis by caspase 3/7., Biosci. Biotechnol. Biochem., 80, 669-675, 2016.
    [PubMed 26786026]
61. Methoxychlor enhances degranulation of murine mast cells by regulating FcεRI-mediated signal transduction., J. Immunotoxicol., 12, 283-289, 2015.
    [PubMed 25418051]
62. Jellyfish collagen stimulates maturation of mouse bone marrow-derived dendritic cells., J. Funct. Foods, 14, 308-317, 2015.
    [ScinceDirect]
63. Ishizuchi dark tea suppresses IgE-mediated degranulation of RBL-2H3 cells and nasal rubbing behavior of pollinosis in mice., J. Funct. Foods, 14, 659-669, 2015.
    [ScinceDirect]
64. Revised stereochemistry of ficifolidione and its biological activities against insects and cells., J. Nat. Prod., 78, 43-49, 2015.
    [PubMed 25495518]
65. Acute larvicidal activity against mosquitoes and oxygen consumption inhibitory activity of dihydroguaiaretic acid derivatives., J. Agric. Food Chem., 63, 2442-2448, 2015.
    [PubMed 25669766]
66. Cytotoxic activity of butane type of 1,7-seco-2,7'-cyclolignanes and apoptosis induction by caspase 9 and 3., Bioorg. Med. Chem. Lett., 24, 4231-4235, 2014.
    [PubMed 25124113]
67. Antiproliferative activity and its underlying mechanisms of methanol extract from leaves of Saururus chinensis (Lour.) Baill. on mouse Colon-26 carcinoma cells., Int. J. Appl. Res. Nat. Prod., 7(3), 17-27, 2014.
68. Activation of J774.1 murine macrophages by lactate dehydrogenase., Cytotechnology, 66, 937-943, 2014.
    [PubMed 24101442]
69. The major whey protein β-lactoglobulin inhibits IgE-mediated degranulation of RBL-2H3 cells and passive cutaneous anaphylaxis in mice., Int. Dairy J., 39, 89-95, 2014.
    [ScienceDirect]
70. Studies on anti-allergic activity of Sargassum horneri extract., J. Funct. Foods, 10, 154-160, 2014.
    [ScienceDirect]
71. Activation of macrophages stimulated by bengkoang fiber extract through Toll-like receptor 4., Food Funct., 5, 1403-1408, 2014.
    [PubMed 24770453]
72. Tributyltin induces cell cycle arrest at G1 phase in the yeast Saccharomyces cerevisiae., J. Toxicol. Sci., 39, 311-317, 2014.
    [PubMed 24646713]
73. Nobiletin, a polymethoxy flavonoid, exerts anti-allergic effect by suppressing activation of phosphoinositide 3-kinase., J. Funct. Foods, 6, 606-614, 2014.
    [ScienceDirect]
74. Jellyfish collagen stimulates production of TNF-α and IL-6 by J774.1 cells through activation of NF-kappaB and JNK via TLR4 signaling pathway., Mol. Immunol., 58, 32-37, 2014.
    [PubMed 24291243]
75. Immunomodulatory activity of bengkoang (Pachyrhizus erosus) fiber extract in vitro and in vivo., Cytotechnology, 66, 75-85, 2014.
    [PubMed 23361525]
76. Quantitative structure-activity relationship analysis of antifungal (+)-dihydroguaiaretic acid using 7-phenyl derivatives., J. Agric. Food. Chem., 61, 8546-8555, 2013.
    [PubMed 23924382]
77. Structure-cytotoxic activity relationship of sesquilignan, Morinol A., Bioorg. Med. Chem. Lett., 23, 4923-4930, 2013.
    [PubMed 23896495]
78. Phenylhydroquinone induces loss of thymocytes through cell cycle arrest and apoptosis elevation in p53-dependent pathway., J. Toxicol. Sci., 38, 325-335, 2013.
    [PubMed 23665931]
79. Effect of bengkoang (Pachyrhizus erosus) fiber extract on murine macrophage-like J774.1 cells and mouse peritoneal macrophages., J. Funct. Foods, 5, 204-210, 2013.
    [ScienceDirect]
80. Inhibitory effect of chlorophyll c2 from brown algae, Sargassum horneri, on degranulation of RBL-2H3 cells., J. Funct. Foods, 5, 204-210, 2013.
    [ScienceDirect]
81. Inhibitory effect of aqueous spinach extract on degranulation of RBL-2H3 cells., Food Chem., 136, 322-327, 2013.
    [ScienceDirect]
    [PubMed 23122065]
82. ラット好塩基球様細胞株RBL-2H3の脱顆粒に及ぼすカゼイン由来ペプチドおよび関連アミノ酸の影響, 日本食品科学工学会誌, 59, 556-561, 2012.
83. Effect of substituents at phenyl group of 7,7'-dioxo-9,9'-epoxylignane on antifungal activity., Bioorg. Med. Chem. Lett., 22, 6740-6744, 2012.
    [PubMed 23017887]
84. Concerted actions of the catechol o-methyltransferase and the cytosolic sulfotransferase SULT1A3 in the metabolism of catecholic drugs., Biochem. Pharmacol., 84, 1186-1195, 2012.
    [PubMed 22917559]
85. Immunomodulatory effects of lactate dehydrogenase in vitro and in vivo., J. Funct. Foods, 4, 972-978, 2012.
    [ScienceDirect]
86. Immunomodulatory effects of citrus fruit auraptene in vitro and in vivo., J. Funct. Foods, 4, 883-890, 2012.
    [ScienceDirect]
87. Immunochromatographic assay of cadmium levels in oysters., Talanta, 97, 262-266, 2012.
    [ScienceDirect]
88. Immunostimulatory effect of beta-cryptoxanthin in vitro and in vivo., J. Funct. Foods, 4, 618-625, 2012.
    [ScienceDirect]
89. Effect of collagens from jellyfish and bovine Achilles tendon on the activity of J774.1 and mouse peritoneal macrophage cells., J. Funct. Foods, 4, 504-512, 2012.
    [ScienceDirect]
90. Immunostimulatory effects of water extract from bulbus arteriosus in tuna in vitro., J. Funct. Foods, 4, 263-270, 2012.
    [ScienceDirect]
91. Nobiletin suppresses adipocyte differentiation of 3T3-L1 cells by an insulin and IBMX mixture induction., Biochim. Biophys. Acta - Gen. Subjects, 1820, 461-468, 2012.
    [PubMed 22172985]
92. Evaluation of immunostimulatory effect of the arrowroot (Maranta arundinacea. L) in vitro and in vivo., Cytotechnology, 64, 131-137, 2012.
    [PubMed 22038480]
93. (-)-Secoisolariciresinol attenuates high-fat diet-induced obesity in C57BL/6 mice., Food Funct., 3, 76-82, 2012.
    [PubMed 22030618]
94. Immunostimulatory effects of collagen from jellyfish in vivo., Cytotechnology, 63, 481-492, 2011.
    [PubMed 21773823]
95. Heavy oil fraction induces the dysplastic sperm in male mouse., J. Toxicol. Sci., 36, 487-491, 2011.
    [PubMed 21804313]
96. Disruption of ion homeostasis by verrucosin and its related compound., Biosci. Biotechnol. Biochem., 75, 1000-1002, 2011.
    [PubMed 21597167]
97. Immunomodulatory effect of (-)-matairesinol in vivo and ex vivo., Biosci. Biotechnol. Biochem., 75, 859-863, 2011.
    [PubMed 21597179]
98. Immunostimulation effects of yellowtail heart extracts in vitro and in vivo., Biosci. Biotechnol. Biochem., 75, 638-645, 2011.
    [PubMed 21512243]
99. Inhibition of myotube formation by paraquat in the myoblast cell line C2C12., J. Toxicol. Sci., 36, 243-246, 2011.
    [PubMed 21467752]
100. Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe., J. Toxicol. Sci. , 243-246, 2011.
     [PubMed 21467752]

101. Immunostimulatory in vitro and in vivo effects of a water-soluble extract from kale., Biosci. Biotechnol. Biochem., 75, 40-46, 2011.
     [PubMed 21228486]
102. Antifungal activity of morinol B derivatives of tetrahydropyran sesquilignan., Biosci. Biotechnol. Biochem., 74, 2071-2076, 2010.
     [PubMed 20944407]
103. IgE suppressive activity of (-)-matairesinol and structure-activity relationship., Biosci. Biotechnol. Biochem., 74, 1878-1883, 2010.
     [PubMed 20834158]
104. Improved syntheses of Morinol C and D by employing Mizoroki-Heck reaction and their cytotoxic and antimicrobial activities., Biosci. Biotechnol. Biochem., 74, 1641-1644, 2010.
     [PubMed 20699576]

105. The effect of secoisolariciresinol on 3T3-L1 adipocytes and the relationship between molecular structure and the activity., Animal Cell Technology: Basic & Applied Aspects, Vol. 16, 345-351, 2010.

106. The effects of pesticides on immune cells., Animal Cell Technology: Basic & Applied Aspects, Vol. 16, 377-382, 2010.

107. The differentiation of myoblast cells to myotube by paraquat., Animal Cell Technology: Basic & Applied Aspects, Vol. 16, 215-219, 2010.

108. Proteose peptone fraction of bovine milk depressed IgE production in vitro and in vivo., Biosci. Biotechnol. Biochem., 74, 1332-1337, 2010.
     [PubMed 20622462]
109. Zebrafish as a model for the study of the phase II cytosolic sulfotransferases., Curr. Drug Metab., 11, 538-546, 2010.
     [PubMed 20545621]
110. In vitro and in vivo anti-tumor effects of novel Span 80 vesicles containing immobilized Eucheuma serra agglutinin., Int. J. Pharm., 389, 157-167, 2010.
     [PubMed 20100554]
111. Oral administration of paraquat perturbs immunoglobulin productivity in mouse., J. Toxicol. Sci., 35, 257-263, 2010.
     [PubMed 20371979]
112. Tributyltin induces Yca1p-dependent cell death of the yeast Saccharomyces cerevisiae., J. Toxicol. Sci., 34, 541-545, 2009.
     [J-STAGE]
113. Heavy oil fractions induce the negative influences on mouse immune system., J. Toxicol. Sci., 34, 459-468, 2009.
     [J-STAGE]
114. White sorghum (Sorghum bicolor (L.) Moench) bran extracts suppressed IgE production by U266 cells., Biosci. Biotechnol. Biochem., 73, 2043-2047, 2009.
     [PubMed 19734654]
115. Antimicrobial activity of stereoisomers of butane type of lignans., Biosci. Biotechnol. Biochem., 73, 1806-1810, 2009.
     [PubMed 19661689]
116. Inhibition of discoloration of yellowtail dark muscle by lignan., Biosci. Biotechnol. Biochem., 73, 1718-1721, 2009.
     [PubMed 19661688]

117. Syntheses and antimicrobial activity of tetrasubstituted tetrahydrofuran lignan stereoisomers., Biosci. Biotechnol. Biochem., 73, 1608-1617, 2009.
     [PubMed 19584535]

118. Abnormal response induced by pesticides on mammalian immune system., Interdisciplinary Studies on Environmental Chemistry Vol.2: Environmental Research in Asia for Establishing a Scientist's Network., 211-218, 2009.

119. Paraquat modulates the differentiation of C2C12 cells to myotube., Interdisciplinary Studies on Environmental Chemistry Vol.2: Environmental Research in Asia for Establishing a Scientist's Network., 219-226, 2009.

120. Severe abnormalities in the reproductive organs of mice caused by the chemical substances contained in heavy oil., J. Toxicol. Sci., 34, 239-244, 2009.
     [J-STAGE]

121. Antimicrobial activity of stereoisomers of morinol A and B, tetrahydropyran sesquineolignan., Biosci. Biotechnol. Biochem., 73,129-133, 2009.
     [PubMed 19129639]

122. The Effect of secoisolariciresinol on 3T3-L1 adipocytes and the relationship between molecular structure and the activity., Biosci. Biotechnol. Biochem., 73, 35-39, 2009.
     [PubMed 19129664]

123. Characterization of amino acid recycling process in yeast autophagy., Interdisciplinary Studies on Environmental Chemistry: Biological Responses to Chemical Pollutants., 241-249, 2008.
124. Vacuolar-type H+-translocating ATPase is the target of tributyltin chloride., Interdisciplinary Studies on Environmental Chemistry: Biological Responses to Chemical Pollutants., 251-261, 2008.
125. Risk assessment of heavy oil on terrestrial mammals., Interdisciplinary Studies on Environmental Chemistry Vol.1: Biological Responses to Chemical Pollutants., 269-274, 2008.
126. The structure-activity relationship of flaxseed lignan, secoisolariciresinol., Interdisciplinary Studies on Environmental Chemistry Vol.1: Biological Responses to Chemical Pollutants., 263-268, 2008.

127. Antioxidant activity of butane type lignans, secoisolariciresinol, dihydroguaiaretic acid, and 7,7'-oxodihydroguaiaretic acid., Biosci. Biotechnol. Biochem., 72, 2981-2986, 2008.
     [PubMed 18997397]

128. The mode of action of the immunostimulatory effect of collagen from jellyfish., Biosci. Biotechnol. Biochem., 72, 2809-0814, 2008.
     [PubMed 18997433]

129. Syntheses of all stereoisomers of goniodiol from yeast-reduction products and their antimicrobiological activity., Biosci. Biotechnol. Biochem., 72, 2342-2352, 2008.
     [PubMed 18776681]

130. Immunostimulation effect of the jellyfish collagen., Animal Cell Technology: Basic & Applied Aspects, Vol. 15, 307-313, 2008.

131. Structure-antibacterial activity relationship of 9-O,9'-O-demethyl (+)-virgatusin., Biosci. Biotechnol. Biochem., 72, 1032-1037, 2008.
     [PubMed 18391445]

132. Effects of polyamines on proliferation and IgM productivity of human-human hybridoma, HB4C5 cells., Cytotechnology, 57, 115-122, 2008.
     [PubMed 19003155]

133. Stereoselective construction of tetra-substituted tetrahydrofuran compounds from benzylic hemiacetal in the presence of H2 and Pd catalyst: stereoselective synthesis of stereoisomer of (-)-virgatusin and antimicrobiological activity., Biosci. Biotechnol. Biochem., 72, 197-203, 2008.
     [PubMed 18175922]

134. First stereoselective synthesis of meso-secoisolariciresinol and comparison of biological activity with (+) and (-)-secoisolariciresinol., Biosci. Biotechnol. Biochem., 71, 2962-2968, 2007.
     [PubMed 18071272]

135. Effect of benzylic structure of lignan on antioxidant activity., Biosci. Biotechnol. Biochem., 71, 2283-2290, 2007.
     [PubMed 17827687]

136. Use of benzyl mesylate for the synthesis of tetrahydrofuran lignan: syntheses of 7,8-trans, 7',8'-trans, 7,7'-cis, 8,8'-cis-virgatusin stereoisomers., Biosci. Biotechnol. Biochem., 71, 2248-2255, 2007.
     [PubMed 17827688]

137. Antimicrobiological activity of lignan: Effect of benzylic oxygen and stereochemistry of 2,3-dibenzyl-4-butanolide and 3,4-dibenzyltetrahydrofuran lignans on activity., Biosci. Biotechnol. Biochem., 71, 1745-1751, 2007.
     [PubMed 17617715]

138. Determination of the stereochemistry of the tetrahydropyran sesquineolignans morinol A and B., J. Nat. Prod., 70, 549-556, 2007.
     [PubMed 17302455]

139. Antifungal activity of tetra-substituted tetrahydrofuran lignan, (-)-virgatusin, and its structure-activity relationship., Biosci. Biotechnol. Biochem., 71, 1028-1035, 2007.
     [PubMed 17420596]

140. Antibacterial activity of virgatusin-related compound., Biosci. Biotechnol. Biochem., 71, 677-680, 2007.
     [PubMed 17341839]

141. Effect of benzylic oxygen on the cytotoxic activity of phenolic lignans., Biosci. Biotechnol. Biochem., 70, 2942-2947, 2006.
     [PubMed 17151475]

142. Immunostimulation effect of the jellyfish collagen., Biosci. Biotechnol. Biochem., 70, 2131-2137, 2006.
     [PubMed 16960386]

143. The anti-tumor effect of Euchema serra agglutinin (ESA) on colon cancer cells in vitro and in vivo., Anti-Cancer Drug., 17, 943-947, 2006.
     [PubMed 16940804]

144. Radical and superoxide scavenging activity of matairesinol and oxidized matairesinol., Biosci. Biotechnol. Biochem., 70, 1934-1940, 2006.
     [PubMed 16926506]

145. Molecular composition of non-ionic vesicles prepared from Span 80 or Span 85 by a two-step emulsification method., J. Disper. Sci. Technol., 27, 1217-1222, 2006.

146. Immunostimulation effect of the fermented milk on human hybridomas and peripheral blood lymphocytes., Animal Cell Technology: Basic & Applied Aspects, Vol. 14, 185-191, 2006.

147. Preparation of cationic immunovesicles containing cationic peptide lipid for specific drug delivery to target cells., Cytotechnology, 47, 51-57, 2005.
     [PubMed 19003044]

148. Immunostimulation effects of proteose-peptone component 3 fragment on human hybridomas and peripheral blood lymphocytes., Biochim. Biophys. Acta, 1725, 233-240, 2005.
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149. Gene transfection into HeLa cells by vesicles containing cationic peptide lipid., Biosci. Biotechnol. Biochem., 69, 1453-1458, 2005.
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150. First enantioselective synthesis of (-)- and (+)-virgatusin, tetra-substituted tetrahydrofuran lignan., Org. Biomol. Chem., 3, 1670-1675, 2005.
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151. Identification of a novel zebrafish SULT1 cytosolic sulfotransferase: cloning, expression, characterization, and developmental expression study., Arch. Biochem. Biophys., 347, 10-19, 2005.
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152. Anti-cancer effect to colon cancer in either vitro or vivo using lipid vesicle combined with alga lectin ESA, Congress Proceedings of 10th The Asian Pacific Confederation of Chemical Engineering Congress, 1P-01-033, 1-10, 2004.

153. Specific targeting at ERM5-1 cell as a model human-brain tumor cell and the anti-tumor effect by using immunovesicle, Congress Proceedings of 10th The Asian Pacific Confederation of Chemical Engineering Congress, 1P-01-032, 1-9, 2004.

154. Lactate dehydrogenase enhances immunoglobulin production by human hybridoma and human peripheral blood lymphocytes., Cytotechnology, 42, 133-143, 2003.
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155. Sulphonation of Dehydroepiandrosterone and Neurosteroids: Molecular cloning, expression, and functional characterization of a novel Zebrafish SULT2Cytosolic Sulphotransferase., Biochem. J., 375, 785-791, 2003.
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156. Sulfonation of environmental estrogens by zebrafish cytosolic sulfotransferases., Biochem. Biophys. Res. Commun., 309, 7-11, 2003.
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157. Sulfation of hydroxychlorobiphenyls: molecular cloning, expression, and functional characterization of zebrafish SULT1 sulfotransferases., Eur. J. Biochem., 270, 2404-2411, 2003.
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158. cDNA Cloning, Expression, and Functional Characterization of A Zebrafish SULT1 Cytosolic Sulfotransferase., Arch. Biochem. Biophys., 414, 67-73, 2003.
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159. High IgM production by human-human hybridoma HB4C5 cells cultured in microtubes., Biosci. Biotechnol. Biochem., 67, 393-395, 2003.
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160. Differential roles of human monoamine (M)-form and simple phenol (P)-form phenol sulfotransferases in drug metabolism., J. Biochem.-Tokyo, 133, 259-262, 2003.
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161. Structure-function relationships in the stereospecific and manganese-dependent dopa/tyrosine sulfation by human M-form phenol sulfotransferase., J. Biol. Chem., 278, 1525-1532, 2003.
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162. Molecular cloning, expression, and functional characterization of a novel zebrafish cytosolic sulfotransferase., Biochem. Biophys. Res. Commun., 300, 725-730, 2003.
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163. Manganese stimulation and stereospecificity of the dopa/tyrosine-sulfating activity of human monoamine-form phenol sulfotransferase: kinetic studies of the mechanism using wild-type and mutant enzymes., J. Biol. Chem., 277, 43813-43820, 2002.
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164. Differential xenoestrogen-sulfating activities of the human cytosolic sulfotransferases: molecular cloning, expression, and purification of human SULT2B1a and SULT2B1b sulfotransferases., Biochim. Biophys. Acta,1573, 165-170, 2002.
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165. Heat denaturation enhanced immunoglobulin production stimulating activity of lysozyme from hen egg white., Biochim. Biophys. Acta, 1572, 19-24, 2002.
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166. Increase of immunoglobulin productivity of human-human hybridoma HB4C5 cells by histone., Biosci. Biotechnol. Biochem., 66, 1241-1245, 2002.
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167. Immunoglobulin production stimulating activity of heat-denatured lysozyme., Animal Cell Technology: Basic & Applied Aspects, Vol. 12, 179-183, 2001.

168. The Cytotoxic effect of Eucheuma serra agglutinin (ESA) on cancer cells and its application to molecular probe for drug delivery system using lipid vesicles., Cytotechnology., 36, 93-99, 2001.
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169. Alcohol dehydrogenase-I from horse liver serves as an immunoglobulin production stimulating factor., Enzyme Microb. Technol., 29, 136-143, 2001.

170. Application of the lipid vesicle immobilized Eucheuma sera lectin for target-specific drug delivery., Proc. of Biotechnology 2000 (The World Congress on Biotechnology), 83-85, 2000.

171. Preparation of an immunovesicle for specific combining to target cells toward either DDS or gene transfection., Proc. of Biotechnology 2000 (The World Congress on Biotechnology), 79-81, 2000.

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174. Study of DDS for cancer therapy applying lipid vesicle immobilizing Eucheuma Serra lectin., Animal Cell Technology: Products from Cells, Cells as Products, 429-431, 1999.

175. The mode of actions of lysozyme as an immunoglobulin production stimulating factor (IPSF)., Animal Cell Technology: Products from Cells, Cells as Products, 43-45, 1999.

176. Effects of DNA on immunoglobulin production stimulating activity of alcohol dehydrogenase., Cytotechnology, 31, 95-102, 1999.

177. Aldolase from rabbit muscle enhances immunoglobulin production by human hybridoma and human peripheral blood lymphocytes., Enzyme Microb. Technol., 24, 41-47, 1999.

178. Inhibition of immunoglobulin production stimulating activity of glyceraldehyde-3-phosphate dehydrogenase by nucleotides., Biosci. Biotech. Biochem., 62, 1237-1239, 1998.
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179. A novel function of enolase from rabbit muscle; an immunoglobulin production stimulating factor., Biochim. Biophys. Acta, 1380, 163-176, 1998.
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180. Spermine enhances IgM productivity of human-human hybridoma HB4C5 cells and human peripheral blood lymphocytes., Cytotechnology, 26, 111-118, 1998.

181. Enhancement of immunoglobulin production of hybridomas and lymphocytes by alcohol dehydrogenase-I., Biochemical Engineering: Marching Toward The Century of Biotechnology, 157-160, 1997.

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185. Enhancement of IgM production by human peripheral blood lymphocytes by rice fermented seasoning under serum-free cultivation., J. Ferment. Bioeng., 82, 77-79, 1996.

186. Effects of sodium poly(styrene sulfonate) on antibody production and cell growth HB4C5 hybridoma cells., Polym. J., 27, 719-727, 1995.

187. Immunoglobulin production stimulating activities of nucleic acid-binding proteins., Animal Cell Technology: Developments towards the 21st Century, 501-507, 1995.

188. Effects of organic pH buffers on cell growth and antibody production of human-human hybridoma HB4C5 cells in a serum-free culture., Cytotechnology, 17, 117-125, 1995.

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192. Synthesis of bis-piperazine-type pH buffer agents and their application to mammalian cell cultures., Biosci. Biotechnol. Biochem., 58, 1370-1375, 1994.

193. Immunoglobulin production stimulating factor (IPSF) derived from Namalwa cells., Animal Cell Technology: Basic & Applied Aspects, Vol. 5, 601-607, 1993.

194. Serum-free culture of human-human hybridoma secreting monoclonal antibody against stomach cancer., Animal Cell Technology: Basic & Applied Aspects, Vol. 4, 321-326, 1992.

195. Virus containment continuous culture of animal cells., Animal Cell Technology: Basic & Applied Aspects, Vol. 4, 233-237, 1992.

196. Purification and characterization of immunoglobulin production stimulating factor-IIβ derived from Namalwa cells., Cytotechnology, 10, 137-146, 1992.

197. Purification and characterization of immunoglobulin production stimulating factor IIα derived from Namalwa cells., Production of Biologicals from Animal Cells in Culture, 735-741, 1991.

198. Immunoglobulin production stimulating factor-IIα (IPSF-IIα) is glyceraldehyde-3-phosphate dehydrogenase like protein., Cytotechnology, 6, 115-120, 1991.

199. Large-scale, high-density freezing of hybridomas and its application to high-density culture., Biotechnol. Bioeng., 38, 1110-1113, 1991.

200. Purification of immunoglobulin production stimulating factor IIα derived from Namalwa cells., Cytotechnology, 5, 255-263, 1991.

201. Enhancement of immunoglobulin production of human-human hybridomas by immunoglobulin production stimulating factors., Trends in Animal Cell Culture Technology, 291-297, 1990.

202. Relationship between oxygen consumption rate and cellular activity of mammalian cells culturedin serum-free media., Biotechnol. Bioeng., 36, 759-762, 1990.

203. Purification and characterization of immunoglobulin production stimulating factor derived from human B lymphoblastoid HO-323 cells., Cytotechnology, 3, 189-197, 1990.

204. Stimulation of proliferation and immunoglobulin M production by lactoferrin in human-human and mouse-mouse hybridomas cultures in serum-free conditions., Cytotechnology, 3, 123-131, 1990.

205. Screening of immunoglobulin production stimulating factor (IPSF) in foodstuffs using human-human hybridoma HB4C5 cells., Agric. Biol. Chem., 53, 2987-2991, 1989.

206. Stimulation of monoclonal antibody production by human-human hybridoma cells with an elevated concentration of potassium or sodium phosphate in serum-free medium., Cytotechnology, 2, 63-67, 1989.

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〜研究テーマのページで要旨公開中〜

1. 「地域の産学による学生への働きかけ」, 就職みらい研究所　就職白書2023　学生の働く組織のより良いつながりに向けて, p. 26-29, 2023.
2. 「産学連携のプログラムで学生のキャリア支援と地域経済への貢献を目指す」, 就職みらい研究所　就職白書2022　就職活動・採用活動の振り返りと今後の見通し, p. 19, 2022.
3. 「機能性食品の開発を核とした食品産業の活性化　-農学研究科附属食品健康科学研究センターの取り組み-」, 松山商工会議所　所報,　760(4), p. 14, 2022.
4. 「ミカンの皮とヨーグルトの組み合わせは花粉症の症状を一掃する！」, マキノ出版ムック ヨーグルト毒出しレシピ, 38-41, 2021.

5. 「動物細胞の生産性を向上する培地添加因子」, BIO INDIUSTRY, 38(3), 30-39, 2021.

6. 「花粉症に特効のミカンの皮」, 安心2021年1月号別冊付録　永久保存版　フルーツ酢, 22-24, 2020.
7. 「みかんってやっぱりからだにいいみたい」, マチボン, 17,　96-95, 2020.
8. 「抗アレルギー・抗肥満効果の健康茶（石鎚黒茶）」, SAKU:Re, 2020秋号, 3, 2020.
9. 「LPS誘発性の過剰炎症反応における河内晩柑果皮水溶性抽出物の抗炎症効果」, 果汁協会報, 739, 12-23, 2020.
10. 「愛媛大学　最先端研究の取り組み2:最先端研究の推進　〜リサーチユニットの形成〜」, 月刊愛媛ジャーナル 新年号, 33, 80-83, 2020.
11. 「柑橘の機能性成分を活用したブランド化と六次産業化」, 果樹の六次産業化の実践 No. 28, 果実日本 11月号, 74(11), 74-78, 2019.
12. 「ミカン酢ヨーグルト」, マキノ出版ムック　ミカン酢でやせる！美肌に変身！」, マキノ出版, 30-32, 2019.
13. 「花粉症に特効のミカンの皮ヨーグルトに酢が加わればさらに効果アップと期待！」, 安心 3月号, 37(3), 33-36, 2019.
14. 「果物の健康効果は、果皮にあり！」, 果実日本 2月号, 74(2), 1, 2019.
15. 「連載・愛媛大学における特色有る取り組み６：最先端研究の推進〜リサーチユニットの形成」, 文部科学教育通信 １月号, 452, 22-23, 2019.
16. 「ミカンの皮とヨーグルトの組み合わせは花粉症の症状を一掃する」, 安心 2月号, 36(2), 94-98, 2018.
17. 「あなたの暮らす街の特産品が秘めたチカラをどれだけ知っていますか　エントリーNo. 50　愛媛県　ハマチ」, 健康365 9月号, 14(9), 161, 2017.
18. 「あなたの暮らす街の特産品が秘めたチカラをどれだけ知っていますか　エントリーNo. 49　愛媛県　温州ミカン」, 健康365 9月号, 14(9), 160-161, 2017.
19. 「ミカンの皮に豊富な特効成分で花粉症の目のかゆみを撃退　丸ごとミカンスムージー」, わかさ 5月号, 28(9), 63-64, 2017.
20. 「ポリメトキシフラボノイドの抗アレルギー活性」, 機能性食品と薬理栄養, 10(6), 354-359, 2017.
21. 「産学官連携における機能性食品開発」, 学術の動向, 22(2), 56-58, 2017.
22. 「ミカンの皮＋飲むヨーグルトの相乗効果」, 現代農業, 96(3), 190-193, 2017.
23. 「愛媛の柑橘果皮を活用した機能性食品開発」, 地方創生に関わる生物工学の取り組み　ー日本各地の活動とネットワークの必要性ー, 日本生物工学会編, 58-60, 2016.
24. 「愛媛大学における機能性食品開発」, 栄養教諭, 45(10), 42-45, 2016.
25. 「ミカン果皮の機能性と商品開発」, 食品と開発, 51(10), 64-66, 2016.
26. 「ブリ心臓でヒトの免疫促進 -加工残渣の有効活用-」、 月刊養殖、49、30-33、2012.
27. 「温州ミカン果皮成分の免疫促進活性」、 月刊FOOD STYLE21、16、45-47、2012.
28. 「水産物資源の有効活用に関する研究 -ハマチ心臓、マグロ動脈球の免疫促進活性について-」、 生物機能研究、15、24-30、2011.

29. 「動物細胞と実験動物を用いた生理活性物質の機能解明」、月刊愛媛ジャーナル、22、60-63、2009.

30. 「界面活性剤を利用したナノカプセルによる薬物運搬体および遺伝子導入体の開発」（共著）、化学と教育、55、184-187、2007.

31. 「食品タンパク質およびペプチドの免疫調節機構」（共著）、生物機能研究会誌、6、25-31、2002.

32. 「癌細胞への標的機能を有する脂質膜ベシクルの創製」（共著）、化学工学シンポジウムシリーズ、76、230-238、2001.

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38. 「コメ発酵エキス中の増殖促進因子、および抗体産生促進因子の検索」、日本農芸化学会誌、70、801-802、1996.

39. Immunoglobulin production stimulating factors., Cell Biology and Biotechnology: Novel Approaches to Increased Cellular Productivity, 35-62, 1993.

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17. 「免疫蛋白質の製造方法」特開2008-212026（2008年9月18日公開）
18. 「脂質膜ベシクルおよびその調製法」：特開2005-068120（2005年3月17日公開）
19. 「脂質膜ベシクルおよび遺伝子を固定化する方法」特開2003-012503（2003年1月15日公開）
20. 「標的指向性を有するベシクル及びその調製法」特開2001-181213（2001年7月3日公開）

1. 愛媛新聞社 愛媛農林水産賞　技術開発賞 （2016年）

2. International Conference on Food Factors (ICoFF) 2011　Poster Award, "Effect of flaxseed lignan on lipid accumulation in adipocytes."（2011年）

3. 日本農芸化学会　日本農芸化学奨励賞（2000年）

現代農業論（学部1回生　前期水曜日1限目）
農学実習IC（農学部1回生　集中）
応用生命化学概論（学部1回生　後期水曜日4限目）
食品健康科学概論（生命機能学科1回生　後期火曜日３限目）

基礎生理学（学部２回生　前期水曜日1限目）
食品機能学（学部２回生　後期火曜日1限目）
コンピュータ演習（学部２回生　後期金曜日３限目）

動物細胞工学（学部３回生　前期火曜日２限目）
生命機能学実験2（学部３回生　前期月、火、水曜日午後）

細胞制御工学（修士１回生　前期第2セメスター金曜2限目）
生命機能学先端研究（修士１回生　後期月曜2限目）
機能性食品開発論（修士１回生　後期第4セメスター木曜2限目）

mars95@agr.ehime-u.ac.jp